Orringer Jeffrey S, Kang Sewon, Maier Lisa, Johnson Timothy M, Sachs Dana L, Karimipour Darius J, Helfrich Yolanda R, Hamilton Ted, Voorhees John J
Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0314, USA.
J Am Acad Dermatol. 2007 Mar;56(3):432-8. doi: 10.1016/j.jaad.2006.10.978. Epub 2007 Jan 18.
There is a need for additional effective treatments for acne vulgaris. Laser therapy has been explored as a therapeutic option for acne, but rigorously designed studies in this area have been limited.
We sought to examine the efficacy of an infrared laser in the treatment of acne.
We conducted a randomized, controlled, single-blind, split-face clinical trial of 46 patients with facial acne. Patients received a series of 3 nonablative laser treatments using a novel neodymium:yttrium-aluminum-garnet (Nd:YAG) laser to half of the face. Serial blinded lesion counts and global acne severity rating of standardized bilateral patient photographs were performed. Sebum production was measured, and patient self-assessment surveys were administered.
A transient but statistically significant improvement in lesion counts of open comedones was demonstrated in treated skin as compared with untreated skin. There were no significant differences between treated and control sides of the face in terms of changes in mean papule or pustule counts. Grading of serial photographs revealed no significant differences between treated and untreated skin. Patient surveys indicated that the majority of patients found the treatments to be at least mildly effective for both acne and oiliness.
The current study only addresses the efficacy of a single laser system employing a specific treatment regimen.
Infrared laser therapy may improve comedonal acne. Additional work is needed to better define the degree and duration of the effect. Patients appear to positively view such therapy for both acne and oily skin.
寻常痤疮需要更多有效的治疗方法。激光疗法已被探索作为痤疮的一种治疗选择，但该领域经过严格设计的研究有限。
我们试图研究红外激光治疗痤疮的疗效。
我们对46例面部痤疮患者进行了一项随机、对照、单盲、半脸的临床试验。患者使用新型钕：钇铝石榴石（Nd:YAG）激光对半边脸进行了一系列3次非剥脱性激光治疗。对标准化的双侧患者照片进行系列盲法皮损计数和整体痤疮严重程度评分。测量皮脂分泌，并进行患者自我评估调查。
与未治疗的皮肤相比，治疗后的皮肤开放性粉刺皮损计数有短暂但具有统计学意义的改善。面部治疗侧和对照侧在平均丘疹或脓疱计数变化方面无显著差异。系列照片分级显示治疗皮肤和未治疗皮肤之间无显著差异。患者调查表明，大多数患者发现该治疗对痤疮和油性皮肤至少有轻度疗效。
本研究仅探讨了采用特定治疗方案的单一激光系统的疗效。
红外激光疗法可能改善粉刺性痤疮。需要进一步开展工作以更好地确定疗效的程度和持续时间。患者似乎对这种治疗痤疮和油性皮肤的方法持积极态度。
