Schmidt J B, Spona J, Niebauer G
Z Hautkr. 1983 Dec 15;58(24):1743-53.
The study presents clinical data and results of skin sebum (SER) determinations during 13-cis-retinoic acid treatment in 15 patients suffering from severe conglobate and cystic acne. The striking clinical improvement was mostly accompanied by decreased SER as well as changes in the composition of the skin surface lipids. While the sebaceous gland lipids were generally reduced, the epidermal lipids showed irregular tendencies. Despite of good therapy effects, 3 patients showed increased SER. This indicates that other mechanisms than those of sebum suppression may be responsible for the treatment success. Sebum suppression and modulation are important and valuable aspects for documentation as well as for elucidation of the working mechanism of 13-cis-retinoic acid.
该研究展示了15例重度聚合性和囊肿性痤疮患者在接受13-顺式维甲酸治疗期间的临床数据以及皮肤皮脂（SER）测定结果。显著的临床改善大多伴随着SER降低以及皮肤表面脂质成分的变化。虽然皮脂腺脂质总体减少，但表皮脂质呈现出不规则的变化趋势。尽管治疗效果良好，但仍有3例患者的SER升高。这表明除皮脂抑制机制外，其他机制可能对治疗成功起作用。皮脂抑制和调节对于记录以及阐明13-顺式维甲酸的作用机制而言是重要且有价值的方面。
