Fasth A, Kaijser B, Olsson R
Allerg Immunol (Leipz). 1983;29(3):149-53.
Serum levels of immunoglobulin class specific antibodies to Tamm-Horsfall protein (TH) were studied in 25 patients with various liver diseases. Increased levels of TH-IgA antibodies were common in different types of liver disease, whereas high TH-IgM concentrations were observed only in patients with primary biliary cirrhosis or chronic active hepatitis. The occurrence of high concentrations of TH antibodies was not related to the occurrence of renal tubular acidosis detected by an acidification test, but the elevation of TH-IgA was significantly correlated to high levels of total serum IgA. An indirect immunofluorescence method did not demonstrate any cross-reaction between TH and liver tissue.
对25例患有各种肝脏疾病的患者的血清中针对Tamm-Horsfall蛋白（TH）的免疫球蛋白类特异性抗体水平进行了研究。TH-IgA抗体水平升高在不同类型的肝脏疾病中很常见，而仅在原发性胆汁性肝硬化或慢性活动性肝炎患者中观察到高浓度的TH-IgM。TH抗体高浓度的出现与酸化试验检测到的肾小管酸中毒的发生无关，但TH-IgA的升高与血清总IgA的高水平显著相关。间接免疫荧光法未显示TH与肝组织之间有任何交叉反应。
