[人外周血淋巴细胞免疫球蛋白合成能力的脉宽调制模型。I. 细胞质免疫球蛋白的荧光光学检测]

[The PWM model of immunoglobulin synthesis capability of human peripheral blood lymphocytes. I. Fluorescence optical detection of cytoplasmic immunoglobulins].

作者信息

Mach D M, Schütt C

出版信息

Allerg Immunol (Leipz). 1983;29(3):168-74.

Abstract

We present an uncomplicated method for valuing the immunoglobulin synthesis of human peripheral blood lymphocytes using the PWM model. The detection of cytoplasmic immunoglobulins was performed by immunofluorescence. We found the following values at normal persons (n = 36): 23,3 +/- 2,8% [cIg]+-cells after PWM stimulation, 5,2 +/- 2,4% after cultivation for 7 days without PWM stimulation and less than 1% without cultivation and mitogenic challenge. Possibilities of application were discussed.

摘要

我们提出了一种使用PWM模型评估人外周血淋巴细胞免疫球蛋白合成的简单方法。通过免疫荧光检测细胞质免疫球蛋白。我们在正常人群（n = 36）中发现以下数值：PWM刺激后[cIg]+细胞为23.3±2.8%，无PWM刺激培养7天后为5.2±2.4%，未培养且无促有丝分裂刺激时低于1%。讨论了其应用可能性。

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