Sridama V, Yang S L, Moawad A, DeGroot L J
Am J Obstet Gynecol. 1983 Nov 1;147(5):566-9. doi: 10.1016/0002-9378(83)90018-2.
Peripheral blood mononuclear cells from patients with preeclampsia were enumerated by means of monoclonal anti-T-cell antibodies. The percentage of total T cells was significantly decreased in this group of patients, as compared with normal term pregnant women. The low proportion of T cells was due to a proportional reduction in both helper and suppressor T cells; therefore, the ratio of helper to suppressor T cells was not different from that in normal pregnant women. There was no correlation between the degree of reduction in percentage of T cells and severity of the disease. The absolute numbers of T cells were slightly, but not significantly, decreased. Our findings support previous evidence of reduced, not increased, immune reactivity in preeclampsia.
采用单克隆抗T细胞抗体对先兆子痫患者的外周血单核细胞进行计数。与足月正常孕妇相比，该组患者的总T细胞百分比显著降低。T细胞比例低是由于辅助性T细胞和抑制性T细胞均成比例减少；因此，辅助性T细胞与抑制性T细胞的比例与正常孕妇无异。T细胞百分比的降低程度与疾病严重程度之间无相关性。T细胞的绝对数量略有减少，但不显著。我们的研究结果支持了先前关于先兆子痫患者免疫反应性降低而非增强的证据。
