运动诱导的小鼠心脏肥大中溶酶体酶活性的变化

Changes in lysosomal enzyme activities in exercise-induced cardiac hypertrophy of mice.

作者信息

Salminen A, Vihko V

出版信息

Comp Biochem Physiol B. 1983;76(1):93-5. doi: 10.1016/0305-0491(83)90176-1.

Abstract

The activities of several lysosomal enzymes were assayed in control and in exercise-hypertrophied cardiac muscle of mice (Mus musculus). The repeated running program increased the activity of beta-glucuronidase (16.1%) in mouse cardiac muscle. Decreased activities of beta-N-acetylglucosaminidase (10.8%), acid ribonuclease (10.7%), and arylsulphatase (14.2%) were observed in the hypertrophied myocardium. The activities of acid deoxyribonuclease, cathepsin C, cathepsin D, and p-nitrophenylphosphatase as well as the activities of citrate synthase and cytochrome c oxidase, mitochondrial enzymes, were unaffected in cardiac muscle. We suggest that lysosomal enzyme responses are selective and highly different in physiologically and pathologically induced cardiac hypertrophies.

摘要

在对照小鼠以及运动性肥大的小鼠（小家鼠）心肌中检测了几种溶酶体酶的活性。重复跑步程序使小鼠心肌中的β-葡萄糖醛酸酶活性增加了16.1%。在肥大心肌中观察到β-N-乙酰氨基葡萄糖苷酶活性降低了10.8%，酸性核糖核酸酶活性降低了10.7%，芳基硫酸酯酶活性降低了14.2%。酸性脱氧核糖核酸酶、组织蛋白酶C、组织蛋白酶D和对硝基苯磷酸酶的活性以及线粒体酶柠檬酸合酶和细胞色素c氧化酶的活性在心肌中未受影响。我们认为，溶酶体酶反应在生理和病理诱导的心肌肥大中具有选择性且差异很大。