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1
Fine specificity analysis of idiotype-specific suppressor factors that block a delayed-type hypersensitivity response to M315: evidence supporting a role for somatic mutations in the variable region of the lambda 2 chain of M315.对阻断针对M315的迟发型超敏反应的独特型特异性抑制因子的精细特异性分析：支持M315的λ2链可变区体细胞突变起作用的证据。
Immunology. 1986 Nov;59(3):365-72.
2
Somatic mutations in the variable region of the lambda 2 chain of M315 suppression of antibodies to the idiotype of M315.M315抗体独特型的M315抑制的λ2链可变区中的体细胞突变。
Biken J. 1985 Dec;28(3-4):51-8.
3
A small hypervariable segment in the variable domain of an immunoglobulin light chain stimulates formation of anti-idiotypic suppressor T cells.免疫球蛋白轻链可变域中的一个小的高变区刺激抗独特型抑制性T细胞的形成。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5396-400. doi: 10.1073/pnas.79.17.5396.
4
T helper cell recognition of idiotopes on lambda 2 light chains of M315 and T952: evidence for dependence on somatic mutations in the third hypervariable region.辅助性T细胞对M315和T952的λ2轻链独特型决定簇的识别：依赖于第三高变区体细胞突变的证据。
Eur J Immunol. 1985 Mar;15(3):278-81. doi: 10.1002/eji.1830150313.
5
Two M315 idiotopes defined by isologous monoclonal antibodies: one depends on germline and the other on mutated murine lambda 2 light chain sequences.由同源单克隆抗体定义的两个M315独特型：一个依赖种系，另一个依赖突变的鼠λ2轻链序列。
Scand J Immunol. 1987 Nov;26(5):535-46. doi: 10.1111/j.1365-3083.1987.tb02287.x.
6
The T lymphocyte response to syngeneic lambda 2 light chain idiotopes. Significance of individual amino acids revealed by variant lambda 2 chains and idiotope-mimicking chemically synthesized peptides.T淋巴细胞对同基因λ2轻链独特型表位的反应。变异λ2链和模拟独特型表位的化学合成肽所揭示的个别氨基酸的意义。
Eur J Immunol. 1986 Aug;16(8):889-93. doi: 10.1002/eji.1830160803.
7
Idiotope-specific T cell clones that recognize syngeneic immunoglobulin fragments in the context of class II molecules.在Ⅱ类分子环境中识别同基因免疫球蛋白片段的独特型特异性T细胞克隆。
Eur J Immunol. 1986 Nov;16(11):1373-8. doi: 10.1002/eji.1830161110.
8
Synthetic peptides and beta-chain gene rearrangements reveal a diversified T cell repertoire for a lambda light chain third hypervariable region.合成肽和β链基因重排揭示了λ轻链第三高变区的多样化T细胞受体库。
Eur J Immunol. 1986 Nov;16(11):1379-84. doi: 10.1002/eji.1830161111.
9
Immune responses to an adjuvant-free native syngeneic myeloma protein (M315).对无佐剂同源骨髓瘤蛋白（M315）的免疫反应。
Eur J Immunol. 1988 Nov;18(11):1785-90. doi: 10.1002/eji.1830181120.
10
Recognition of lambda 1 and lambda 2 murine light chains by carrier-specific isologous T helper cells; effect of L-H chain assembly.载体特异性同源T辅助细胞对λ1和λ2小鼠轻链的识别；L-H链组装的影响。
Eur J Immunol. 1983 May;13(5):353-9. doi: 10.1002/eji.1830130502.

引用本文的文献

1
Activation of idiotype-specific CD4+ T-cell line: cellular processing of exogenous self-immunoglobulin.独特型特异性CD4 + T细胞系的激活：外源性自身免疫球蛋白的细胞处理
Immunology. 1990 Oct;71(2):153-7.

本文引用的文献

1
Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.利用具有独特型或抗独特型受体的可溶性T细胞衍生因子选择性抑制抗半抗原反应的主要独特型成分。
J Exp Med. 1980 May 1;151(5):1213-31. doi: 10.1084/jem.151.5.1213.
2
Mouse myeloma proteins with lambda 2 and lambda 3 light chains.带有λ2和λ3轻链的小鼠骨髓瘤蛋白。
J Immunol. 1981 Nov;127(5):2150-5.
3
Amino acid sequence diversity in mouse lambda 2 variable regions.小鼠λ2可变区的氨基酸序列多样性
J Immunol. 1984 Nov;133(5):2757-61.
4
Suppressor cells and immunoregulation.抑制细胞与免疫调节。
Annu Rev Immunol. 1984;2:127-57. doi: 10.1146/annurev.iy.02.040184.001015.
5
T-cell helper circuits.T细胞辅助回路
Immunol Rev. 1984 Jun;79:87-102. doi: 10.1111/j.1600-065x.1984.tb00488.x.
6
T helper cells recognize an idiotope located on peptide 88-114/117 of the light chain variable domain of an isologous myeloma protein (315).辅助性T细胞识别位于同源骨髓瘤蛋白轻链可变区肽段88 - 114/117上的独特型表位（315）。
J Exp Med. 1983 Dec 1;158(6):2183-8. doi: 10.1084/jem.158.6.2183.
7
A small hypervariable segment in the variable domain of an immunoglobulin light chain stimulates formation of anti-idiotypic suppressor T cells.免疫球蛋白轻链可变域中的一个小的高变区刺激抗独特型抑制性T细胞的形成。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5396-400. doi: 10.1073/pnas.79.17.5396.
8
Structural relationships between carrier epitopes and antigenic epitopes on hen egg-white lysozyme.鸡卵清溶菌酶上载体表位与抗原表位之间的结构关系。
Immunology. 1982 May;46(1):145-54.
9
Antigen recognition by T cells. I. Suppressor T cells fail to recognize cross-reactivity between native and denatured ovalbumin.T细胞的抗原识别。I. 抑制性T细胞无法识别天然和变性卵清蛋白之间的交叉反应性。
J Immunol. 1980 Oct;125(4):1515-20.
10
Antigen recognition by T cells and B cells: recognition of cross-reactivity between native and denatured forms of globular antigens.T细胞和B细胞的抗原识别：球状抗原天然形式与变性形式之间交叉反应性的识别。
Clin Immunol Immunopathol. 1980 Mar;15(3):397-408. doi: 10.1016/0090-1229(80)90051-3.

对阻断针对M315的迟发型超敏反应的独特型特异性抑制因子的精细特异性分析：支持M315的λ2链可变区体细胞突变起作用的证据。

Fine specificity analysis of idiotype-specific suppressor factors that block a delayed-type hypersensitivity response to M315: evidence supporting a role for somatic mutations in the variable region of the lambda 2 chain of M315.

作者信息

Sakato N, Azuma T, Fujio H

出版信息

Immunology. 1986 Nov;59(3):365-72.

PMID:2431996
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453194/
Abstract

The delayed-type hypersensitivity (DTH) response in BALB/c mice to the idiotype of M315 (alpha,lambda 2), a BALB/c myeloma protein, can be suppressed by a single i.v. injection of soluble M315. This suppression involves the generation of suppressor T cells. Mice tolerized by M315 produce subcellular factors that suppress the M315-DTH response. Such suppressor factors can be obtained by mechanical disruption of spleen cells or thymocytes from mice treated i.v. with M315. The fine specificity of the factor was studied using various immunoadsorbents such as L315 and germline V lambda 2 chain-Sepharose beads with known amino acid sequences. The results indicated that the specificity of the factor depended on three contiguous somatically mutated amino acid residues, Phe94, Arg95 and Asn96, in the third hypervariable region of the V domain of the L chain of M315.

摘要

BALB/c小鼠对BALB/c骨髓瘤蛋白M315（α，λ2）独特型的迟发型超敏反应（DTH），可通过静脉内单次注射可溶性M315来抑制。这种抑制涉及抑制性T细胞的产生。经M315耐受的小鼠产生可抑制M315-DTH反应的亚细胞因子。此类抑制因子可通过机械破碎经静脉注射M315处理的小鼠的脾细胞或胸腺细胞获得。使用各种免疫吸附剂，如具有已知氨基酸序列的L315和种系Vλ2链-琼脂糖珠，研究了该因子的精细特异性。结果表明，该因子的特异性取决于M315轻链V结构域第三个高变区中三个相邻的体细胞突变氨基酸残基，即苯丙氨酸94、精氨酸95和天冬酰胺96。