Binderup L
Ann Rheum Dis. 1983 Dec;42(6):687-92. doi: 10.1136/ard.42.6.687.
The role of macrophages and of macrophage-lymphocyte co-operation in the induction of T-suppressor cell activity in rats with adjuvant arthritis was investigated. Macrophages from arthritic rats had no direct effect on the induction of T-suppressor cells, but, in the presence of arthritic rats' lymphocytes or supernatants from such lymphocytes, macrophages inhibited the induction of T-suppressor cell activity. Addition of indomethacin during the induction of T-suppressor cells reduced the inhibitory effects, suggesting that prostaglandins released from lymphocyte-activated macrophages might be involved in the defective induction of T-suppressor cell activity in rats with adjuvant arthritis.
研究了巨噬细胞以及巨噬细胞与淋巴细胞的合作在佐剂性关节炎大鼠中诱导T抑制细胞活性方面的作用。来自关节炎大鼠的巨噬细胞对T抑制细胞的诱导没有直接影响，但是，在存在关节炎大鼠的淋巴细胞或这些淋巴细胞的上清液的情况下，巨噬细胞会抑制T抑制细胞活性的诱导。在诱导T抑制细胞期间添加消炎痛可降低抑制作用，这表明淋巴细胞活化的巨噬细胞释放的前列腺素可能参与了佐剂性关节炎大鼠中T抑制细胞活性诱导缺陷。
