Queiros M V, Rocha B
Clin Exp Immunol. 1983 Nov;54(2):509-14.
The distribution of T cell subsets in the peripheral blood lymphocytes of 50 patients with rheumatoid arthritis (RA) and 28 controls was evaluated using the monoclonal anti-human T cell antibodies, alpha-Leu 1, alpha-Leu 2a and alpha-Leu 3a. A reduced number of cells with Leu 2a phenotype was observed in the group of patients with active RA. When patients were classified according to both disease activity and the presence of IgG or IgM immunocomplexes, a good correlation was observed between reduced Leu 2a+ numbers and the presence of IgG immunocomplexes. Patients without serum IC had normal numbers of Leu 2a T cells, independently of the activity of the disease. The significance of these results to the understanding of the aetiopathogenesis of RA is discussed.
采用单克隆抗人T细胞抗体α-Leu 1、α-Leu 2a和α-Leu 3a，对50例类风湿性关节炎（RA）患者和28例对照者外周血淋巴细胞中的T细胞亚群分布进行了评估。在活动期RA患者组中，观察到具有Leu 2a表型的细胞数量减少。当根据疾病活动度和IgG或IgM免疫复合物的存在对患者进行分类时，观察到Leu 2a +细胞数量减少与IgG免疫复合物的存在之间存在良好的相关性。无血清免疫复合物（IC）的患者，无论疾病活动度如何，Leu 2a T细胞数量均正常。讨论了这些结果对理解RA发病机制的意义。
