Monto A S, Ross H W
Am J Epidemiol. 1978 Jan;107(1):57-64. doi: 10.1093/oxfordjournals.aje.a112508.
The relationship of acute respiratory illness and infection to chronic bronchitis was investigated in the community of Tecumseh, Michigan. Families were randomly selected for study from among all those in the community and they were followed for periods of one year. Occurrence of acute respiratory illnesses was identified on a weekly basis. Frequency of chronic symptoms of cough and sputum production was separately ascertained. Lung function studies were performed three times during the course of the surveillance year and blood specimens were collected at those times. The blood specimens were tested for rise in antibody titer with antigens of type A and B influenza, respiratory syncytial virus and Mycoplasma pneumoniae. Adults with mild or intermittent chronic symptoms of cough and sputum production experienced more acute respiratory illness than those without these symptoms. This finding was present at different levels of smoking frequency. A similar relationship was present when serologic infection rates were used in the analysis instead of acute illness incidence. When the population was dichotomized on the basis of lung function data, the segment of the population with more depressed values was found to have experienced higher infection rates. The results suggest that acute infection may play an independent role in the pathogenesis of chronic respiratory disease.
在密歇根州蒂康塞社区，对急性呼吸道疾病及感染与慢性支气管炎之间的关系进行了调查。从该社区所有家庭中随机选取家庭进行研究，并对他们随访一年。每周确定急性呼吸道疾病的发生情况。分别确定咳嗽和咳痰等慢性症状的出现频率。在监测年度内进行三次肺功能研究，并在这些时间采集血样。检测血样中针对甲型和乙型流感、呼吸道合胞病毒及肺炎支原体抗原的抗体滴度升高情况。有轻度或间歇性咳嗽和咳痰慢性症状的成年人比没有这些症状的成年人患急性呼吸道疾病更多。这一发现存在于不同吸烟频率水平。当分析中使用血清学感染率而非急性疾病发病率时，也存在类似关系。根据肺功能数据将人群分为两组时，发现肺功能值较低的人群感染率较高。结果表明，急性感染可能在慢性呼吸道疾病的发病机制中起独立作用。
