Ehle A L, Stewart R M, Lellelid N A, Leventhal N A
Arch Neurol. 1984 Apr;41(4):379-82. doi: 10.1001/archneur.1984.04050160041013.
Pattern-reversal visual (PRVEPs), brain-stem auditory (BAEPs), and somatosensory (SSEPs) evoked potentials were studied in 12 patients with Huntington's disease (HD) and were repeated in eight at one and two years. The mean cortical SSEP amplitude was decreased compared with that of age-matched controls, with a trend of decreasing amplitude with increasing duration and severity of illness. The SSEP latency was not significantly different from that of controls. The PRVEPs and BAEPs were normal. The serial studies showed a progressive decrease in amplitude of the SSEP over a two-year period. These neurophysiological findings may reflect the pathological involvement of the thalamus reported for HD. While evoked potentials are not of use in individual case diagnosis, the SSEP may be an objective physiological method for following the course of the disease in HD and the effects of therapeutic intervention in patient populations.
对12例亨廷顿舞蹈病（HD）患者进行了图形翻转视觉诱发电位（PRVEP）、脑干听觉诱发电位（BAEP）和体感诱发电位（SSEP）研究，并对其中8例患者在1年和2年时进行了重复检查。与年龄匹配的对照组相比，皮质SSEP的平均波幅降低，且随着病程和病情严重程度的增加有波幅降低的趋势。SSEP潜伏期与对照组无显著差异。PRVEP和BAEP均正常。系列研究显示，在两年期间SSEP波幅逐渐降低。这些神经生理学发现可能反映了HD中报道的丘脑病理受累情况。虽然诱发电位对个别病例诊断无用，但SSEP可能是一种客观的生理学方法，用于跟踪HD患者的病程以及治疗干预对患者群体的影响。
