Josiassen R C, Shagass C, Mancall E L, Roemer R A
Electroencephalogr Clin Neurophysiol. 1984 Feb;57(2):113-8. doi: 10.1016/0013-4694(84)90169-x.
Auditory and visual evoked potentials elicited by acoustic click (AEP) and checkerboard pattern flash (VEP) were recorded from 15 locations in 21 patients with Huntington's disease (HD) and 21 controls matched for age and sex. Peak latencies were approximately the same for both groups, except that AEP peak N100 appeared earlier in HDs. The main deviation in HDs consisted of generally reduced amplitude of VEP and AEP components; these deviations can be considered non-specific. Early VEP and AEP peaks contained no specific abnormalities comparable to those found in early somatosensory evoked potentials, as previously reported for the same subjects. VEP and AEP amplitudes were lower in medicated than in unmedicated HD patients, but amplitudes for both medicated and unmedicated HDs deviated from normal. Drugs may act to further diminish the already lower than normal amplitudes in HDs.
对21例亨廷顿舞蹈病（HD）患者和21例年龄及性别匹配的对照组，从15个部位记录了由听性咔嗒声诱发的听觉诱发电位（AEP）和棋盘格模式闪光诱发的视觉诱发电位（VEP）。两组的峰潜伏期大致相同，只是HD患者的AEP峰N100出现得更早。HD患者的主要偏差在于VEP和AEP成分的波幅普遍降低；这些偏差可被视为非特异性的。早期VEP和AEP峰未发现与先前报道的同一受试者早期体感诱发电位中所见的特异性异常相当的情况。用药的HD患者的VEP和AEP波幅低于未用药的患者，但用药和未用药的HD患者的波幅均偏离正常。药物可能会进一步降低HD患者本来就低于正常的波幅。
