一项关于免疫球蛋白E的基因研究。
A genetic study of immunoglobulin E.
作者信息
Gerrard J W, Rao D C, Morton N E
出版信息
Am J Hum Genet. 1978 Jan;30(1):46-58.
Abstract
Path analysis gives evidence of genetic heritability (.425) for serum IgE levels. Complex segregation analysis indicates, in addition to significant polygenic heritability, a major regulatory locus RE, with homozygotes re/re maintaining persistently high levels of IgE. The gene frequency of re is .489, and the displacement is 1.67 standard deviations.
摘要
路径分析显示血清IgE水平存在遗传遗传性（0.425）。复杂分离分析表明，除了显著的多基因遗传性外，还有一个主要调控位点RE，纯合子re/re的IgE水平持续维持在高水平。re的基因频率为0.489，位移为1.67个标准差。
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