地塞米松抑制试验在内源性抑郁症中的诊断价值研究

Study of the diagnostic value of the dexamethasone suppression test in endogenous depression.

作者信息

Aguilar M T, Lemaire M, Castro P, Libotte M, Reynders J, Herchuelz A

出版信息

J Affect Disord. 1984 Feb;6(1):33-42. doi: 10.1016/0165-0327(84)90006-5.

Abstract

The diagnostic value of the dexamethasone suppression test (DST) in "endogenous" depression was evaluated in 209 psychiatric inpatients. A high incidence of abnormal DST results was observed in "endogenous" depressives (52%), schizo-affective (69%) and borderline patients (38%). However, 25% of the patients with other psychiatric disease also failed to suppress on the DST. Diagnostic criteria, previous history of alcoholism, psychiatric drug treatment, age and sex did not significantly affect DST performance. The present data do not indicate that the DST represents a highly specific marker of "endogenous" depression.

摘要

对209名精神科住院患者评估了地塞米松抑制试验（DST）在“内源性”抑郁症中的诊断价值。在“内源性”抑郁症患者（52%）、精神分裂症伴情感障碍患者（69%）和边缘性患者（38%）中观察到DST结果异常的高发生率。然而，25%患有其他精神疾病的患者在DST中也未能被抑制。诊断标准、既往酗酒史、精神科药物治疗、年龄和性别对DST结果没有显著影响。目前的数据并不表明DST是“内源性”抑郁症的高度特异性标志物。