Miyawaki T, Seki H, Moriya N, Nagaoki T, Kubo M, Okuda N, Taniguchi N
Clin Exp Immunol. 1980 Apr;40(1):161-7.
The generation of immunoglobulin-producing cells from human peripheral blood lymphocytes in pokeweed mitogen-simulated cultures was significantly suppressed by levamisole. Greatest suppression was observed when cells were incubated with levamisole at a concentration of 10(-6) M for 20 min or more prior to culture. Such suppression occurred when untreated as well as levamisole-treated B cells were co-cultured only with levamisole-treated T cells. Adding of levamisole-treated T cells to a combination of untreated autologous B and T cells resulted in the suppression of B cell differentiation. The results suggest that levamisole treatment of lymphocytes exerts suppression on pokeweed mitogen-induced B cell differentiation through its effect on T cell regulatory properties.
在商陆丝裂原刺激的培养物中，左旋咪唑可显著抑制人外周血淋巴细胞产生免疫球蛋白的细胞生成。当细胞在培养前与浓度为10(-6) M的左旋咪唑孵育20分钟或更长时间时，观察到最大程度的抑制。当未处理的B细胞以及经左旋咪唑处理的B细胞仅与经左旋咪唑处理的T细胞共培养时，会出现这种抑制。将经左旋咪唑处理的T细胞添加到未处理的自体B细胞和T细胞的组合中会导致B细胞分化受到抑制。结果表明，淋巴细胞经左旋咪唑处理后，通过其对T细胞调节特性的影响，对商陆丝裂原诱导的B细胞分化产生抑制作用。
