Schurr W, Knoll B, Ziegler R, Anders R, Merkle H P
J Endocrinol Invest. 1985 Feb;8(1):41-4. doi: 10.1007/BF03350636.
Four different modes of TRH application (400 micrograms iv, 1 mg nasal, 10 mg buccal and 40 mg oral) were investigated in young healthy subjects for evaluation of thyrotropin (TSH) and prolactin (PRL) stimulation. Plasma TSH, PRL, T4, T3, thyroxine-binding-globulin (TBG) were measured by radioimmunoassay. There were significant increases of TSH and PRL following TRH stimulation by all test forms. Bolus injection of TRH led to maximal TSH and PRL plasma levels within 20 min to 30 min, compared with 30 min to 45 min following nasal administration. Buccal and oral application produced more prolonged TSH and PRL increases, achieving plateau levels after 120 min to 180 min. Stimulated PRL levels were higher in women than in men. Uniformity of PRL response was better after iv or nasal than buccal and oral TRH stimulation. Known side effects were lower after nasal than iv TRH application. Buccal and oral administration provoked no side effects. Nasal TRH application seems to be a well suited test form for TSH and PRL stimulation.
在年轻健康受试者中研究了四种不同的促甲状腺激素释放激素（TRH）给药方式（静脉注射400微克、鼻腔给药1毫克、口腔给药10毫克和口服40毫克），以评估促甲状腺激素（TSH）和催乳素（PRL）的刺激情况。采用放射免疫分析法测定血浆TSH、PRL、T4、T3、甲状腺素结合球蛋白（TBG）。所有测试形式的TRH刺激后，TSH和PRL均显著升高。静脉推注TRH后，TSH和PRL血浆水平在20分钟至30分钟内达到峰值，而鼻腔给药后则为30分钟至45分钟。口腔和口服给药使TSH和PRL升高的时间更长，在120分钟至180分钟后达到平台期。刺激后的PRL水平女性高于男性。静脉注射或鼻腔给药后PRL反应的一致性优于口腔和口服TRH刺激。鼻腔TRH给药后的已知副作用低于静脉注射。口腔和口服给药未引起副作用。鼻腔TRH给药似乎是一种非常适合用于TSH和PRL刺激的测试形式。
