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1
The murine lymphocyte receptor for IgE. II. Characterization of the multivalent nature of the B lymphocyte receptor for IgE.小鼠IgE淋巴细胞受体。II. B淋巴细胞IgE受体多价性质的特征
J Exp Med. 1984 Jun 1;159(6):1790-5. doi: 10.1084/jem.159.6.1790.
2
The murine lymphocyte receptor for IgE. I. Isolation and characterization of the murine B cell Fc epsilon receptor and comparison with Fc epsilon receptors from rat and human.小鼠IgE淋巴细胞受体。I. 小鼠B细胞Fcε受体的分离与特性鉴定以及与大鼠和人类Fcε受体的比较。
J Immunol. 1984 Feb;132(2):796-803.
3
Characterization of the murine T cell receptor for IgE (Fc epsilon RII). Demonstration of shared and unshared epitopes with the B cell Fc epsilon RII.小鼠IgE（FcεRII）T细胞受体的特性。与B细胞FcεRII共享和非共享表位的证明。
J Immunol. 1988 Oct 15;141(8):2661-7.
4
Murine B cell hybridomas bearing ligand-inducible Fc receptors for IgE.携带IgE配体诱导型Fc受体的小鼠B细胞杂交瘤。
J Immunol. 1986 Jun 15;136(12):4573-80.
5
Characterization of a monoclonal antibody directed against the murine B lymphocyte receptor for IgE.一种针对小鼠IgE B淋巴细胞受体的单克隆抗体的特性分析
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6
Characterization of the low-affinity receptor for IgE on murine B cells by using membrane impermeant cross-linking reagents.使用膜不通透性交联试剂对小鼠B细胞上IgE低亲和力受体的表征
Int Arch Allergy Appl Immunol. 1985;77(1-2):228-31. doi: 10.1159/000233795.
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The murine lymphocyte receptor for IgE. III. Use of chemical cross-linking reagents to further characterize the B lymphocyte Fc epsilon receptor.小鼠IgE淋巴细胞受体。III. 使用化学交联试剂进一步表征B淋巴细胞Fcε受体。
J Immunol. 1985 Jan;134(1):518-25.
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The expression of B cell surface receptors. III. The murine low-affinity IgE Fc receptor is not expressed on Ly 1 or 'Ly 1-like' B cells.
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引用本文的文献

1
CD23/Fc epsilon RII and its soluble fragments can form oligomers on the cell surface and in solution.CD23/FcεRII及其可溶性片段可在细胞表面和溶液中形成寡聚体。
Immunology. 1995 Feb;84(2):202-6.
2
A versatile and potentially general approach to the targeting of specific cell types by retroviruses: application to the infection of human cells by means of major histocompatibility complex class I and class II antigens by mouse ecotropic murine leukemia virus-derived viruses.一种通用且可能具有广泛适用性的逆转录病毒靶向特定细胞类型的方法：通过小鼠嗜亲性鼠白血病病毒衍生病毒借助主要组织相容性复合体I类和II类抗原感染人类细胞的应用。
Proc Natl Acad Sci U S A. 1989 Dec;86(23):9079-83. doi: 10.1073/pnas.86.23.9079.
3
Low affinity IgE receptors (Fc epsilon RII).低亲和力IgE受体（FcεRII）
Clin Rev Allergy. 1989 Summer;7(2):165-92. doi: 10.1007/BF02914465.

本文引用的文献

1
Composition and subunit structure of the cell receptor for immunoglobulin E.免疫球蛋白E细胞受体的组成与亚基结构
J Biol Chem. 1980 Oct 10;255(19):9060-6.
2
Fc receptors specific for IgE on subpopulations of human lymphocytes and monocytes.人类淋巴细胞和单核细胞亚群上对IgE具有特异性的Fc受体。
Clin Immunol Immunopathol. 1980 Mar;15(3):424-33. doi: 10.1016/0090-1229(80)90054-9.
3
Mechanism of binding of multivalent immune complexes to Fc receptors. 1. Equilibrium binding.多价免疫复合物与Fc受体的结合机制。1. 平衡结合。
Biochemistry. 1981 Oct 27;20(22):6326-34. doi: 10.1021/bi00525a007.
4
Biotinylation of human C3.人补体C3的生物素化
Mol Immunol. 1982 Jul;19(7):857-64. doi: 10.1016/0161-5890(82)90351-0.
5
Lymphocytes bearing Fc receptors for IgE.带有IgE的Fc受体的淋巴细胞。
Immunol Rev. 1981;56:199-218. doi: 10.1111/j.1600-065x.1981.tb01052.x.
6
Lymphocytes bearing Fc receptor for IgE. VIII. Affinity of mouse IgE for Fc epsilon R on Mouse B lymphocytes.带有IgE Fc受体的淋巴细胞。VIII. 小鼠IgE对小鼠B淋巴细胞上FcεR的亲和力。
J Immunol. 1982 May;128(5):2306-12.
7
The murine lymphocyte receptor for IgE. I. Isolation and characterization of the murine B cell Fc epsilon receptor and comparison with Fc epsilon receptors from rat and human.小鼠IgE淋巴细胞受体。I. 小鼠B细胞Fcε受体的分离与特性鉴定以及与大鼠和人类Fcε受体的比较。
J Immunol. 1984 Feb;132(2):796-803.
8
Purification of Fc epsilon receptors and Fc gamma receptors.
Methods Enzymol. 1983;93:178-89. doi: 10.1016/s0076-6879(83)93042-2.
9
Properties of two monoclonal antibodies directed against the Fc and Fab' regions of rat IgE.两种针对大鼠IgE的Fc和Fab'区域的单克隆抗体的特性。
Int Arch Allergy Appl Immunol. 1983;70(4):352-60. doi: 10.1159/000233347.
10
Characterization of the target cell receptor for IgE. II. Polyacrylamide gel analysis of the surface IgE receptor from normal rat mast cells and from rat basophilic leukemia cells.IgE靶细胞受体的特性。II. 正常大鼠肥大细胞和大鼠嗜碱性白血病细胞表面IgE受体的聚丙烯酰胺凝胶分析。
J Immunol. 1976 Feb;116(2):319-26.

小鼠IgE淋巴细胞受体。II. B淋巴细胞IgE受体多价性质的特征

The murine lymphocyte receptor for IgE. II. Characterization of the multivalent nature of the B lymphocyte receptor for IgE.

作者信息

Lee W T, Conrad D H

出版信息

J Exp Med. 1984 Jun 1;159(6):1790-5. doi: 10.1084/jem.159.6.1790.

DOI:10.1084/jem.159.6.1790
PMID:6233388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187318/
Abstract

The murine B lymphocyte Fc epsilon R is functionally multivalent. Radiolabeled rat IgE, when bound to the B cell Fc epsilon R will co-isolate with the Fc epsilon R on a rat IgE affinity column; examination of the affinity column eluate by SDS-PAGE reveals the component previously identified as the Fc epsilon R as well as E and L chains from IgE. At low levels of Fc epsilon R saturation, up to 30% of the Fc epsilon R bound IgE becomes bound to IgE-Affi-Gel. By using a biotin-avidin system, the coprecipitation of non-haptenated IgE with haptenated IgE was examined and the results suggest (but do not prove) a divalent receptor.

摘要

小鼠B淋巴细胞FcεR在功能上是多价的。放射性标记的大鼠IgE与B细胞FcεR结合后，会在大鼠IgE亲和柱上与FcεR共同分离；通过SDS-PAGE对亲和柱洗脱液进行检测，可发现先前鉴定为FcεR的成分以及IgE的E链和L链。在低水平的FcεR饱和状态下，高达30%与FcεR结合的IgE会与IgE-亲和凝胶结合。利用生物素-抗生物素蛋白系统，检测了未结合半抗原的IgE与结合半抗原的IgE的共沉淀情况，结果提示（但未证实）存在二价受体。