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小鼠IgE淋巴细胞受体。II. B淋巴细胞IgE受体多价性质的特征

The murine lymphocyte receptor for IgE. II. Characterization of the multivalent nature of the B lymphocyte receptor for IgE.

作者信息

Lee W T, Conrad D H

出版信息

J Exp Med. 1984 Jun 1;159(6):1790-5. doi: 10.1084/jem.159.6.1790.

DOI:10.1084/jem.159.6.1790
PMID:6233388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187318/
Abstract

The murine B lymphocyte Fc epsilon R is functionally multivalent. Radiolabeled rat IgE, when bound to the B cell Fc epsilon R will co-isolate with the Fc epsilon R on a rat IgE affinity column; examination of the affinity column eluate by SDS-PAGE reveals the component previously identified as the Fc epsilon R as well as E and L chains from IgE. At low levels of Fc epsilon R saturation, up to 30% of the Fc epsilon R bound IgE becomes bound to IgE-Affi-Gel. By using a biotin-avidin system, the coprecipitation of non-haptenated IgE with haptenated IgE was examined and the results suggest (but do not prove) a divalent receptor.

摘要

小鼠B淋巴细胞FcεR在功能上是多价的。放射性标记的大鼠IgE与B细胞FcεR结合后，会在大鼠IgE亲和柱上与FcεR共同分离；通过SDS-PAGE对亲和柱洗脱液进行检测，可发现先前鉴定为FcεR的成分以及IgE的E链和L链。在低水平的FcεR饱和状态下，高达30%与FcεR结合的IgE会与IgE-亲和凝胶结合。利用生物素-抗生物素蛋白系统，检测了未结合半抗原的IgE与结合半抗原的IgE的共沉淀情况，结果提示（但未证实）存在二价受体。

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本文引用的文献

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Composition and subunit structure of the cell receptor for immunoglobulin E.免疫球蛋白E细胞受体的组成与亚基结构
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Fc receptors specific for IgE on subpopulations of human lymphocytes and monocytes.人类淋巴细胞和单核细胞亚群上对IgE具有特异性的Fc受体。
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Mechanism of binding of multivalent immune complexes to Fc receptors. 1. Equilibrium binding.多价免疫复合物与Fc受体的结合机制。1. 平衡结合。
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Biotinylation of human C3.人补体C3的生物素化
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Lymphocytes bearing Fc receptors for IgE.带有IgE的Fc受体的淋巴细胞。
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Lymphocytes bearing Fc receptor for IgE. VIII. Affinity of mouse IgE for Fc epsilon R on Mouse B lymphocytes.带有IgE Fc受体的淋巴细胞。VIII. 小鼠IgE对小鼠B淋巴细胞上FcεR的亲和力。
J Immunol. 1982 May;128(5):2306-12.
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The murine lymphocyte receptor for IgE. I. Isolation and characterization of the murine B cell Fc epsilon receptor and comparison with Fc epsilon receptors from rat and human.小鼠IgE淋巴细胞受体。I. 小鼠B细胞Fcε受体的分离与特性鉴定以及与大鼠和人类Fcε受体的比较。
J Immunol. 1984 Feb;132(2):796-803.
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Purification of Fc epsilon receptors and Fc gamma receptors.
Methods Enzymol. 1983;93:178-89. doi: 10.1016/s0076-6879(83)93042-2.
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Properties of two monoclonal antibodies directed against the Fc and Fab' regions of rat IgE.两种针对大鼠IgE的Fc和Fab'区域的单克隆抗体的特性。
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Characterization of the target cell receptor for IgE. II. Polyacrylamide gel analysis of the surface IgE receptor from normal rat mast cells and from rat basophilic leukemia cells.IgE靶细胞受体的特性。II. 正常大鼠肥大细胞和大鼠嗜碱性白血病细胞表面IgE受体的聚丙烯酰胺凝胶分析。
J Immunol. 1976 Feb;116(2):319-26.

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