Vogel R, Deaney N B, Round E M, VandenBurg M J, Currie W J
J Antimicrob Chemother. 1984 May;13 Suppl B:113-20. doi: 10.1093/jac/13.suppl_b.113.
The results of clinical trials in which norfloxacin was used for 7 days compared with amoxycillin or cotrimoxazole, or for 3 days compared with citrated nalidixic acid, are presented. Additionally, the results of a concurrent open study of 3 days of norfloxacin in the management of simple urinary tract infections are discussed. Resistance to norfloxacin was only encountered in 0.2% of pathogens isolated. Norfloxacin was as effective in eradicating bacteriuria as amoxycillin, cotrimoxazole or citrated nalidixic acid. The response to 3 days of norfloxacin was similar to that seen after 7 days therapy with this compound, or to 7 days of cotrimoxazole. The incidence of adverse experiences to norfloxacin in 758 patients was below 10%.
本文展示了诺氟沙星与阿莫西林或复方新诺明相比使用7天，以及与枸橼酸萘啶酸相比使用3天的临床试验结果。此外，还讨论了一项关于诺氟沙星治疗单纯性尿路感染3天的同期开放性研究结果。分离出的病原体中仅0.2%对诺氟沙星耐药。诺氟沙星在根除菌尿方面与阿莫西林、复方新诺明或枸橼酸萘啶酸同样有效。使用诺氟沙星3天的效果与使用该化合物7天的效果相似，或与使用复方新诺明7天的效果相似。758例患者中诺氟沙星不良反应的发生率低于10%。
