Salthouse T N
J Biomed Mater Res. 1984 Apr;18(4):395-401. doi: 10.1002/jbm.820180407.
The macrophage plays a pivotal role in both wound healing and cellular response to implants, including percutaneous devices. Within twenty-four hours macrophages were found in close contact with the implant surface. Eventually fibroplasts and connective tissue proliferate, and finally the implant will be encapsulated. The presence of macrophages is essential for the activation of collagen synthesis by fibroplasts . Implant shape and surface can profoundly affect macrophage behavior. At rough implant surfaces macrophages with giant cells are present for many months with the possibility of chronic granulomatous reactions. Superior tissue compatibility should be associated with smooth, well contoured implants with no acute angles.
巨噬细胞在伤口愈合以及包括经皮装置在内的植入物的细胞反应中都起着关键作用。在24小时内就发现巨噬细胞与植入物表面紧密接触。最终，成纤维细胞和结缔组织会增殖，最后植入物将被包裹起来。巨噬细胞的存在对于成纤维细胞激活胶原蛋白合成至关重要。植入物的形状和表面会深刻影响巨噬细胞的行为。在粗糙的植入物表面，带有巨细胞的巨噬细胞会存在数月之久，有可能引发慢性肉芽肿反应。良好的组织相容性应该与表面光滑、轮廓良好且无锐角的植入物相关。
