Okabe N, Mori R, Miake S, Inoue K
J Clin Lab Immunol. 1984 Apr;13(4):167-9.
It is well established that Concanavalin A (Con A)-induced human peripheral blood lymphocytes exert suppressive effects on mitogen-induced proliferation of responder cells. Using peripheral blood lymphocytes from healthy individuals, effects of antithyroid drugs on Con A-induced suppressor function were studied. We found an enhancement of Con A-stimulated suppressor activity by MMI and PTU in all these subjects. In the light of these data, an enhancement in suppressor activity by antithyroid drugs may contribute, in part, to a remission of Graves' disease.
众所周知，伴刀豆球蛋白A（Con A）诱导的人外周血淋巴细胞对丝裂原诱导的反应细胞增殖具有抑制作用。利用健康个体的外周血淋巴细胞，研究了抗甲状腺药物对Con A诱导的抑制功能的影响。我们发现，在所有这些受试者中，甲巯咪唑（MMI）和丙硫氧嘧啶（PTU）均可增强Con A刺激的抑制活性。根据这些数据，抗甲状腺药物抑制活性的增强可能部分有助于格雷夫斯病的缓解。
