Brzezińska-Błaszczyk E
Arch Immunol Ther Exp (Warsz). 1983;31(6):863-70.
The relation between IgE antibodies of different specificity in in vivo sensitization of mouse mast cells were studied. In the system of active immunization with EA and KLH mixed with Al(OH)3 no inhibition of an IgE and IgGl response to one antigen by simultaneous administration of other antigen was observed. The lack of inhibition was reflected in serum anti-EA and anti-KLH antibody levels as well as in mast cell sensitization expressed in antigen-induced histamine release. Furthermore, we were unable to detect an inhibitory effect of active immunization of mice with EA on in vivo passive sensitization of peritoneal mast cells. These observations indicated that in such a system immunization actively produced IgE antibodies do not saturate mast cell IgE receptors and do not inhibit subsequent sensitization of these cells with IgE antibodies of another specificity.
研究了小鼠肥大细胞体内致敏中不同特异性IgE抗体之间的关系。在将EA和KLH与氢氧化铝混合进行主动免疫的系统中，未观察到同时给予其他抗原会抑制对一种抗原的IgE和IgG1反应。这种抑制作用的缺乏反映在血清抗EA和抗KLH抗体水平以及抗原诱导的组胺释放所表达的肥大细胞致敏中。此外，我们未能检测到用EA对小鼠进行主动免疫对腹膜肥大细胞体内被动致敏的抑制作用。这些观察结果表明，在这样的系统中，主动产生的IgE抗体不会使肥大细胞IgE受体饱和，也不会抑制这些细胞随后被另一种特异性IgE抗体致敏。
