抗小鼠IgE对小鼠和大鼠肥大细胞的作用。
Action of anti-mouse IgE on mouse and rat mast cells.
作者信息
Wyczólkowska J, Maśliński C
出版信息
Acta Allergol. 1976 Jun;31(3):175-83.
The action of anti-mouse IgE on normal or sensitized mouse and rat peritoneal mast cells as well as on the reaginic activity of mouse and rat antisera was studied. Anti-mouse IgE induced histamine release from normal mouse peritoneal mast cells in vitro and this effect was greatly enhanced when mast cells were actively sensitized. The action of anti-mouse IgE on normal rat peritoneal mast cells was slight; it was enhanced after sensitization of these cells with mouse reaginic antibodies as well as after active sensitization. Moreover, anti-mouse IgE is able to neutralise the reaginic activity of mouse and rat antisera. The results suggest that there exist some functional and structural similarities between mouse and rat IgE.
研究了抗小鼠IgE对正常或致敏小鼠及大鼠腹膜肥大细胞的作用，以及对小鼠和大鼠抗血清的反应素活性的作用。抗小鼠IgE在体外可诱导正常小鼠腹膜肥大细胞释放组胺，当肥大细胞被主动致敏时，这种作用会大大增强。抗小鼠IgE对正常大鼠腹膜肥大细胞的作用轻微；在用小鼠反应素抗体致敏这些细胞后以及主动致敏后，其作用增强。此外，抗小鼠IgE能够中和小鼠和大鼠抗血清的反应素活性。结果表明，小鼠和大鼠IgE之间存在一些功能和结构上的相似性。
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