类风湿关节炎中体外自发产生 IgM 类风湿因子时辅助性 T 细胞功能增强。
Enhanced T helper cell function for the spontaneous production of IgM rheumatoid factor in vitro in rheumatoid arthritis.
作者信息
Patel V, Panayi G S
出版信息
Clin Exp Immunol. 1984 Jun;56(3):584-92.
Co-culture experiments between T and B cells from normal subjects and rheumatoid arthritis (RA) patients were performed in order to assess the immunoregulatory effects of T cells on spontaneous production of IgM rheumatoid factor (IgM-RF). Cultures of normal B cells with normal, autologous or allogeneic T cells failed to synthesize IgM-RF. In contrast, RAT cells promoted IgM-RF production from normal B cells as well as from RA B cells. The 'helper' effect of T cells from RA patients for IgM-RF production was not HLA-DR4 restricted and could not be accounted for by an allogeneic effect. These observations suggest that activated T helper cells may contribute to the production of IgM-RF in RA.
为了评估T细胞对类风湿因子（IgM-RF）自发产生的免疫调节作用，对正常受试者和类风湿关节炎（RA）患者的T细胞与B细胞进行了共培养实验。正常B细胞与正常、自体或异体T细胞共培养时无法合成IgM-RF。相比之下，RA患者的T细胞可促进正常B细胞以及RA患者B细胞产生IgM-RF。RA患者T细胞对IgM-RF产生的“辅助”作用不受HLA-DR4限制，也不能用异体效应来解释。这些观察结果表明，活化的T辅助细胞可能在RA中促成IgM-RF的产生。
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