Griffaton G, Freyss-Béguin M, Millanvoye-Van Brussel E, Dupuy F, Millart H, Lowy R, Lechat P
C R Seances Soc Biol Fil. 1984;178(2):130-5.
Three indexes of partial oxygen deprivation, i.e. hypoxanthine, alpha HBDH and CK, were investigated in rat heart cell cultures, 7 day-old. Enzyme release in the medium and hypoxanthine uptake by the cells pointed out both oxygen and glucose deprivation, which modelized ischemia. Conversely, hypoxanthine release pointed out oxygen deprivation, in the presence of glucose however, which modelized hypoxia, whereas there was no enzyme leakage in the latter condition.
在7日龄大鼠心脏细胞培养物中研究了部分氧剥夺的三个指标，即次黄嘌呤、α-羟丁酸脱氢酶（αHBDH）和肌酸激酶（CK）。培养基中的酶释放和细胞对次黄嘌呤的摄取表明存在氧和葡萄糖剥夺，这模拟了缺血。相反，在有葡萄糖存在的情况下，次黄嘌呤释放表明存在氧剥夺，这模拟了缺氧，而在后一种情况下没有酶泄漏。
