仓鼠模型中胰腺癌发生的改变。十五、烟酰胺的预防作用。
Modification of pancreatic carcinogenesis in the hamster model. XV. Preventive effect of nicotinamide.
作者信息
Pour P M, Lawson T
出版信息
J Natl Cancer Inst. 1984 Sep;73(3):767-70.
The induction of pancreatic ductal-ductular adenomas (P = .05) and carcinomas (P less than .0001) by N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4; 2,2'-dioxo-N-nitrosodipropylamine] in Syrian golden hamsters was inhibited by nicotinamide (NA) (350 mg/kg body wt, ip) administered 10 minutes before and 3 hours after a single dose of BOP (10 mg/kg body wt, sc). The anticancer effect of NA and its relatively low toxicity in humans may provide a new lead in human cancer prevention.
在叙利亚金仓鼠中，N-亚硝基双（2-氧代丙基）胺[（BOP），化学物质登记号：60599-38-4；2,2'-二氧代-N-亚硝基二丙胺]诱导胰腺导管-小导管腺瘤（P = 0.05）和癌（P < 0.0001）的作用，受到烟酰胺（NA）（350毫克/千克体重，腹腔注射）的抑制，NA在单次给予BOP（10毫克/千克体重，皮下注射）前10分钟和后3小时给药。NA的抗癌作用及其在人体中相对较低的毒性，可能为人类癌症预防提供新的线索。
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