Ryden S, Bergqvist L, Hafström L, Strand S E
Eur J Cancer Clin Oncol. 1983 Jul;19(7):965-70. doi: 10.1016/0277-5379(83)90066-4.
The function of the reticuloendothelial system (RES) was evaluated after the inoculation of an experimental tumor in rats. Four groups were studied according to tumor size and site. Reticuloendothelial function was evaluated by measuring the biokinetics of a standardized [99Tcm]-sulfur colloid. Estimation of the uptake rate of the labeled colloid into the liver and other parts of the RES was performed through the use of a two-compartment model. Animals with small liver or subcutaneous tumors showed an increased activity of both the hepatic and the extrahepatic RES. Animals with large retroperitoneal tumors showed a significant decrease in the RE function of the liver. In these animals the function of the extrahepatic RES was not changed compared to controls but was, however, significantly decreased compared to animals with smaller tumors. The findings may reflect a difference in the impact of tumor size on RE function extra- and intrahepatically.
在给大鼠接种实验性肿瘤后，对其网状内皮系统（RES）的功能进行了评估。根据肿瘤大小和部位将大鼠分为四组。通过测量标准化的[99Tcm] - 硫胶体的生物动力学来评估网状内皮功能。通过使用双室模型来估计标记胶体在肝脏和RES其他部位的摄取率。肝脏或皮下小肿瘤的动物肝脏和肝外RES的活性均增加。患有大的腹膜后肿瘤的动物肝脏的RE功能显著降低。在这些动物中，肝外RES的功能与对照组相比没有变化，但与肿瘤较小的动物相比显著降低。这些发现可能反映了肿瘤大小对肝内外RE功能影响的差异。
