Groggins R C, Milner A D, Stokes G M
Arch Dis Child. 1981 May;56(5):342-4. doi: 10.1136/adc.56.5.342.
The bronchodilator activity in nebulised salbutamol, ipratropium bromide, clemastine, and a placebo was studied in 14 asthmatic children aged between 3 and 5 years. Changes in lung function were monitored by measuring peak expiratory flow rate and total respiratory resistance using a modification of the forced oscillation technique. Ipratropium bromide produced a degree of bronchodilation similar to that of salbutamol, but the bronchodilatory activity of clemastine was not appreciably better than for the placebo.
对14名3至5岁的哮喘儿童进行了研究，观察雾化沙丁胺醇、异丙托溴铵、氯马斯汀和一种安慰剂的支气管扩张活性。通过使用改良的强迫振荡技术测量呼气峰值流速和总呼吸阻力来监测肺功能变化。异丙托溴铵产生的支气管扩张程度与沙丁胺醇相似，但氯马斯汀的支气管扩张活性并不明显优于安慰剂。
