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虹膜炎患者血清中巨噬细胞移动抑制因子增加。

Increase of macrophage migration inhibitory factor in sera of patients with iridocyclitis.

作者信息

Kitaichi N, Kotake S, Mizue Y, Matsuda H, Onoé K, Nishihira J

机构信息

Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Japan.

出版信息

Br J Ophthalmol. 2000 Dec;84(12):1423-5. doi: 10.1136/bjo.84.12.1423.

DOI:10.1136/bjo.84.12.1423
PMID:11090487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1723331/
Abstract

AIMS

To determine whether macrophage migration inhibitory factor (MIF) levels were increased in sera of the patients with iridocyclitis.

METHODS

Sera were obtained from 41 patients with acute iridocyclitis, 13 patients with chronic iridocyclitis, and 44 healthy control subjects. MIF levels were determined by a human MIF ELISA.

RESULTS

The average levels of MIF in the sera of patients with both acute and chronic iridocyclitis were significantly higher than that of healthy subjects.

CONCLUSION

Uveitis induces the elevation of serum MIF, which may affect various inflammatory symptoms in uveitis.

摘要

目的

确定虹膜睫状体炎患者血清中巨噬细胞移动抑制因子(MIF)水平是否升高。

方法

采集41例急性虹膜睫状体炎患者、13例慢性虹膜睫状体炎患者和44例健康对照者的血清。采用人MIF酶联免疫吸附测定法测定MIF水平。

结果

急性和慢性虹膜睫状体炎患者血清中MIF的平均水平均显著高于健康受试者。

结论

葡萄膜炎可导致血清MIF升高,这可能影响葡萄膜炎的各种炎症症状。

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本文引用的文献

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Different influence of macrophage migration inhibitory factor (MIF) in signal transduction pathway of various T cell subsets.巨噬细胞移动抑制因子(MIF)在不同T细胞亚群信号转导途径中的不同影响。
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Inhibition of experimental autoimmune uveoretinitis with anti-macrophage migration inhibitory factor antibodies.抗巨噬细胞移动抑制因子抗体对实验性自身免疫性葡萄膜视网膜炎的抑制作用。
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Increased production of macrophage migration inhibitory factor by PBMCs of atopic dermatitis.特应性皮炎患者外周血单核细胞巨噬细胞移动抑制因子产生增加。
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Prominent increase of macrophage migration inhibitory factor in the sera of patients with uveitis.
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Macrophage migration inhibitory factor is an essential immunoregulatory cytokine in atopic dermatitis.巨噬细胞移动抑制因子是特应性皮炎中一种重要的免疫调节细胞因子。
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MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response.巨噬细胞移动抑制因子的重新发现:细胞因子、垂体激素以及糖皮质激素诱导的免疫反应调节因子
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Detection and immunolocalization of macrophage migration inhibitory factor in rat iris and ciliary epithelium.大鼠虹膜和睫状体上皮中巨噬细胞移动抑制因子的检测与免疫定位
Immunol Lett. 1996 Oct;53(1):1-5. doi: 10.1016/0165-2478(96)02600-4.
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MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia.巨噬细胞移动抑制因子是一种源自垂体的细胞因子,可增强致死性内毒素血症。
Nature. 1993 Oct 21;365(6448):756-9. doi: 10.1038/365756a0.