Kubo C, Johnson B C, Day N K, Good R A
J Nutr. 1984 Oct;114(10):1884-99. doi: 10.1093/jn/114.10.1884.
It is frequently stated that high fat diets are harmful with respect to nutrition and disease development. Herein, (NZB/NZW)F1 autoimmune-prone mice were compared under the influence of different calorie intakes and different calorie sources. Decreased calorie intake prolonged life and delayed onset of glomerulonephritis. This influence of restriction of energy intake was greater than any influences of dietary energy source. Parameters affected strictly by restricted calorie intake were: 1) longevity, 2) delayed onset of glomerulonephritis, 3) greatly decreased circulating immune complexes, 4) decreased production of anti-DNA antibodies, 5) increased thymocyte proliferation in response to exogenous Interleukin-2 (IL-2), 6) increased IL-2 production by spleen cells stimulated by concanavalin A and 7) marked increase of mixed lymphocyte reaction of spleen cells. Parameters affected both by restriction of calorie intake and by high sucrose content in full-fed mice and not obviously related to longevity and protection from glomerulonephritis were: 1) plaque-forming cell response to sheep red blood cells in vitro and 2) cytotoxic cell-mediated immune response generated by in vitro exposure to allogenic antigen.
人们常说高脂肪饮食在营养和疾病发展方面是有害的。在此，对（新西兰黑/新西兰白）F1自身免疫易感性小鼠在不同热量摄入和不同热量来源的影响下进行了比较。热量摄入减少可延长寿命并延迟肾小球肾炎的发病。能量摄入限制的这种影响大于饮食能量来源的任何影响。严格受热量摄入限制影响的参数有：1）寿命，2）肾小球肾炎发病延迟，3）循环免疫复合物大幅减少，4）抗DNA抗体产生减少，5）对外源白细胞介素-2（IL-2）反应的胸腺细胞增殖增加，6）伴刀豆球蛋白A刺激的脾细胞产生IL-2增加，7）脾细胞混合淋巴细胞反应显著增加。受热量摄入限制以及饱食小鼠高蔗糖含量影响且与寿命和预防肾小球肾炎无明显关联的参数有：1）体外对绵羊红细胞的空斑形成细胞反应，2）体外暴露于同种异体抗原产生的细胞毒性细胞介导的免疫反应。
