Kubo C, Johnson B C, Gajjar A, Good R A
J Nutr. 1987 Jun;117(6):1129-35. doi: 10.1093/jn/117.6.1129.
When the energy intake of (NZB X NZW)F1 female mice was reduced to 60% of the intake of simultaneously ad libitum-fed mice, the early death associated with autoimmune-based renal disease in this strain was greatly delayed. The length of prolongation of disease-free life depended not only on the decreased energy intake but also on the energy source. In the group of mice with 60% intake of a carbohydrate-free (i.e., high fat) diet, mean longevity was doubled as compared to that of ad libitum-fed mice. However, when the nonprotein energy was supplied by carbohydrate (sucrose and glycerol) the mean longevity was three times that of the ad libitum-fed groups, although survival times varied widely. With ad libitum feeding the nonprotein energy source did not significantly affect longevity. Clearly, although energy intake restriction provides significant influence on longevity, very high fat diets do not give the same protection as do high carbohydrate diets. The basis for this difference is not entirely clear and several explanations are possible.
当将（新西兰黑鼠×新西兰白鼠）F1代雌性小鼠的能量摄入降低至同时自由采食小鼠摄入量的60%时，该品系中与自身免疫性肾病相关的早期死亡被大大延迟。无病生存期延长的时长不仅取决于能量摄入的减少，还取决于能量来源。在摄入无碳水化合物（即高脂肪）饮食量为60%的小鼠组中，平均寿命与自由采食小鼠相比延长了一倍。然而，当非蛋白能量由碳水化合物（蔗糖和甘油）提供时，平均寿命是自由采食组的三倍，尽管存活时间差异很大。自由采食时，非蛋白能量来源对寿命没有显著影响。显然，尽管能量摄入限制对寿命有显著影响，但高脂肪饮食并不能像高碳水化合物饮食那样提供相同的保护作用。这种差异的原因尚不完全清楚，可能有几种解释。
