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同基因MRL小鼠之间骨髓嵌合体中移植物抗宿主病的单向发生。

One-way occurrence of graft-versus-host disease in bone marrow chimaeras between congenic MRL mice.

作者信息

Fujiwara M, Kariyone A

出版信息

Immunology. 1984 Oct;53(2):251-6.

PMID:6237981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454822/
Abstract

Bone marrow cells (BMCs) of MRL/Mp-lpr/lpr (MRL/l) mice, when infused into irradiated MRL/Mp-+/+ (MRL/n) mice, induced graft-versus-host disease (GVHD) and recipients died of wasting syndromes beginning around a few weeks later. Protracted appearance of GVHD was observed when (MRL/n X MRL/l) F1 mice were used as recipients of MRL/l BMSs. On the other hand, MRL/n BMCs did not elicit GVHD in irradiated MRL/l mice. Treatment of MRL/l BMCs with anti-Thy-l antiserum plus complement did not eliminate GVHD-provoking capacity. Thymectomy of the recipents reduced the incidence of GVHD. No apparent reaction was observed in mutual mixed lymphocyte culture of spleen cells from MRL/l and MRL/n mice. These data suggest that injected T cell precursors of MRL/l mice become mature through the host (MRL/n mice) thymus and appear in the periphery as functioning T cells, resulting in the appearance of GVHD.

摘要

将MRL/Mp-lpr/lpr（MRL/l）小鼠的骨髓细胞（BMCs）注入经照射的MRL/Mp-+/+（MRL/n）小鼠体内时，会引发移植物抗宿主病（GVHD），受体小鼠大约在几周后开始死于消瘦综合征。当将（MRL/n×MRL/l）F1小鼠用作MRL/l骨髓干细胞（BMSs）的受体时，观察到GVHD的持续出现。另一方面，MRL/n BMCs在经照射的MRL/l小鼠中不会引发GVHD。用抗Thy-1抗血清加补体处理MRL/l BMCs并不能消除引发GVHD的能力。受体小鼠胸腺切除可降低GVHD的发生率。在MRL/l和MRL/n小鼠脾细胞的相互混合淋巴细胞培养中未观察到明显反应。这些数据表明，注入的MRL/l小鼠T细胞前体通过宿主（MRL/n小鼠）胸腺成熟，并作为有功能的T细胞出现在外周，导致GVHD的出现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/843f/1454822/cde1ee0f80c3/immunology00199-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/843f/1454822/cde1ee0f80c3/immunology00199-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/843f/1454822/cde1ee0f80c3/immunology00199-0068-a.jpg

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本文引用的文献

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Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells.BXSB 小鼠中雄性决定的加速自身免疫性疾病：通过骨髓和脾细胞进行转移。
J Immunol. 1980 Sep;125(3):1032-6.
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Specific immune suppression in adult mice across K-I-D fully allogeneic histoincompatibility barriers induced by lymphocyte-free bone marrow cells.无淋巴细胞的骨髓细胞在完全异基因组织相容性屏障的成年小鼠中诱导的跨K-I-D的特异性免疫抑制。
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Attenuation of lpr-graft-versus-host disease (GVHD) in MRL/lpr spleen cell-injected SCID mice by in vivo treatment with anti-V beta 8.1,2 monoclonal antibody.通过用抗Vβ8.1,2单克隆抗体进行体内治疗，减轻注射MRL/lpr脾细胞的SCID小鼠的lpr移植物抗宿主病（GVHD）。
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Spontaneous autocytotoxicity against an unexpected H-2d haplotype in MRL/lpr (H-2k) autoimmune disease-prone mice.在易患自身免疫性疾病的MRL/lpr（H-2k）小鼠中，针对意外的H-2d单倍型的自发自身细胞毒性。
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Resistance of MRL/Mp-lpr/lpr mice to tolerance induction.
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