小鼠腹膜巨噬细胞对微生物进行最大程度的细胞内杀伤所需的血清蛋白的细胞外刺激。
Extracellular stimulation by serum proteins required for maximal intracellular killing of microorganisms by mouse peritoneal macrophages.
作者信息
Leijh P C, van Zwet T L, van Furth R
出版信息
Infect Immun. 1984 Dec;46(3):754-8. doi: 10.1128/iai.46.3.754-758.1984.
Abstract
Intracellular killing of catalase-positive Staphylococcus aureus by resident mouse peritoneal macrophages was very low in the absence of serum but maximal in the presence of fresh normal serum. A large proportion of catalase-negative Streptococcus pyogenes were killed in the absence of extracellular serum, and maximal killing was reached only when serum was present extracellularly. Further investigations revealed that stimulation of intracellular killing by extracellular serum is dependent on the interaction of immunoglobulin G and Fc receptors and of complement component C3b with C3b receptors in the macrophage membrane.
摘要
在无血清的情况下，驻留小鼠腹膜巨噬细胞对过氧化氢酶阳性金黄色葡萄球菌的细胞内杀伤作用非常低，但在有新鲜正常血清存在时则达到最大值。在无细胞外血清的情况下，很大一部分过氧化氢酶阴性化脓性链球菌被杀死，只有当血清存在于细胞外时才达到最大杀伤效果。进一步的研究表明，细胞外血清对细胞内杀伤的刺激作用取决于免疫球蛋白G和Fc受体以及补体成分C3b与巨噬细胞膜上C3b受体的相互作用。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Participation of immunoglobulins and complement components in the intracellular killing of Staphylococcus aureus and Escherichia coli by human granulocytes.免疫球蛋白和补体成分在人粒细胞对金黄色葡萄球菌和大肠杆菌的细胞内杀伤中的作用。
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