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氨甲酰聚草氨酸生物合成中氮的来源。

Origin of nitrogen in the biosynthesis of carbamoylpolyoxamic acid.

作者信息

Isono K, Crain P F, McCloskey J A

出版信息

Biomed Mass Spectrom. 1978 Jan;5(1):89-90. doi: 10.1002/bms.1200050118.

DOI:10.1002/bms.1200050118
PMID:623901
Abstract

The biosynthetic origin of the carbamoylpolyoxamic sidechain of the polyoxin nucleoside peptide antibiotics was studied using 15N labeled alpha-amino-S-hydroxyvaleric acid as precursor. Gas chromatography mass spectrometry of polyoxamic acid isolated from culture filtrates of Streptomyces cacaoi var. asoensis showed incorporation of the nitrogen atom of alpha-amino-S-hydroxyvaleric acid into carbamoylpolyoxamic acid with an isotopic dilution factor of 23, thus establishing the intermediacy of alpha-amino-S-hydroxyvaleric acid and determination of the full biosynthetic pathway.

摘要

使用15N标记的α-氨基-S-羟基戊酸作为前体，研究了多氧菌素核苷肽抗生素的氨甲酰基聚氧肟酸侧链的生物合成起源。从可可链霉菌变种浅黄变种的培养滤液中分离出的聚氧肟酸的气相色谱-质谱分析表明，α-氨基-S-羟基戊酸的氮原子以同位素稀释因子23掺入氨甲酰基聚氧肟酸中，从而确定了α-氨基-S-羟基戊酸的中间体作用并确定了完整的生物合成途径。

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