Skaarup P, Jørgensen T, Larsen S
Scand J Urol Nephrol. 1984;18(4):351-6. doi: 10.3109/00365598409180210.
A case of asynchronous renal carcinoma with a 15-year course is described. Right nephrectomy and left heminephrectomy were performed. Solitary metastases to pancreas and striated muscle were treated with total pancreatectomy and local excision, respectively. The patient died of renal failure due to progressive immune complex glomerulonephritis, which was documented histologically as well as by clinical observations of intensifying excretion of urinary protein with decreasing selectivity. The glomerular lesion is suggested to have been caused by deposition of tumour-related immune complexes arising from an immune response by the host to his tumour.
本文描述了一例病程长达15年的异时性肾癌病例。患者接受了右肾切除术和左半肾切除术。胰腺和横纹肌的孤立性转移灶分别接受了全胰切除术和局部切除术。患者死于进行性免疫复合物性肾小球肾炎导致的肾衰竭，组织学检查以及临床观察均证实了这一点，表现为尿蛋白排泄增加且选择性降低。推测肾小球病变是由宿主对肿瘤的免疫反应产生的肿瘤相关免疫复合物沉积所致。
