Pollen J J, Witztum K, Basarab R
Urology. 1984 Dec;24(6):632-8. doi: 10.1016/0090-4295(84)90122-5.
Patients with prostatic cancer frequently require evaluation of bony metastases as well as renal function. 99mTc-methylene diphosphonate, a commonly used bone-imaging agent, is about 60 per cent localized in the bony skeleton and about 40 per cent excreted by the kidneys. Immediate imaging after intravenous injection of the isotope may yield high-quality radionuclide nephrourograms, which provide excellent visual and graphic displays of renal anatomy and excretory function. Our preliminary studies suggest that the immediate 99mTc-methylene diphosphonate scan may usefully expand the value of a routine bone scan to screen for ureteral obstruction. Patients with underlying malignancy who require simultaneous evaluation and follow-up of bony metastases and renal function might be conveniently served by the dual functions of the expanded bone scan to include immediate imaging of the kidneys.
前列腺癌患者经常需要评估骨转移情况以及肾功能。99m锝-亚甲基二膦酸盐是一种常用的骨显像剂，约60%沉积于骨骼，约40%经肾脏排泄。静脉注射该同位素后立即进行显像，可获得高质量的放射性核素肾输尿管造影图，能很好地显示肾脏的解剖结构和排泄功能。我们的初步研究表明，99m锝-亚甲基二膦酸盐立即扫描可能有助于扩大常规骨扫描在筛查输尿管梗阻方面的价值。需要同时评估和随访骨转移及肾功能的潜在恶性肿瘤患者，可通过扩展骨扫描的双重功能（包括对肾脏的立即显像）得到便利的检查。
