Barnett M A, Rolland J M, Learmonth R P, Walters W A, Pihl E
Aust N Z J Obstet Gynaecol. 1984 Aug;24(3):202-5. doi: 10.1111/j.1479-828x.1984.tb01490.x.
Peripheral blood lymphocyte subclasses were studied by flow cytofluorimetry and monoclonal antibodies in 21 women with Pregnancy Induced Hypertension (PIH), 20 healthy women in their third trimester of pregnancy and in 20 nulliparous, nonpregnant women. The cells were stained with the monoclonal antibodies OKT3, OKT4 and OKT8 to define total T cells, T helper cells (Th) and T suppressor-cytotoxic cells (Ts/c) respectively. B lymphocytes were defined by their surface immunoglobulin. Absolute numbers of total T cells and Ts/c cells were significantly decreased (p less than 0.05) in patients with PIH compared to either control group. The proportion of B lymphocytes was significantly (p less than 0.01) increased and absolute numbers were marginally increased. These findings reflect an immune disturbance which may be of prime importance in the pathogenesis of this disease.
采用流式细胞荧光测定法和单克隆抗体，对21例妊娠高血压综合征（PIH）患者、20例孕晚期健康孕妇及20例未孕未产妇女的外周血淋巴细胞亚群进行了研究。用单克隆抗体OKT3、OKT4和OKT8对细胞进行染色，分别以确定总T细胞、T辅助细胞（Th）和T抑制-细胞毒性细胞（Ts/c）。B淋巴细胞通过其表面免疫球蛋白来确定。与对照组相比，PIH患者的总T细胞和Ts/c细胞的绝对数量显著减少（p<0.05）。B淋巴细胞的比例显著增加（p<0.01），绝对数量略有增加。这些发现反映了一种免疫紊乱，这可能在该疾病的发病机制中至关重要。
