Olton D S, Walker J A, Gage F H
Brain Res. 1978 Jan 13;139(2):295-308. doi: 10.1016/0006-8993(78)90930-7.
Rats were tested in a new spatial discrimination procedure which measured working memory. Following preoperative testing, lesions were placed to disrupt each of the major extrinsic fiber connections of the hippocampal formation. Destruction of the entorhinal area, body of the fimbria-fornix anterior to hippocampus, septum, or postcommisural fornix produced a severe and consistent impairment in performance. Analysis of error patterns indicated that when animals with limbic lesions made errors, they were likely to make these errors in the same sequence as the original choices. These data support the hypothesis that the hippocampus has an important role in the processing of information about spatial location, and that normal performance on this task requires an intact hippocampal circuitry.
大鼠在一种新的测量工作记忆的空间辨别程序中接受测试。术前测试后，对海马结构的每个主要外在纤维连接进行损伤。内嗅区、海马前方的穹窿 - 穹窿脚体、隔区或连合后穹窿的破坏会导致严重且持续的行为表现受损。错误模式分析表明，当患有边缘系统损伤的动物犯错时，它们很可能按照与最初选择相同的顺序犯错。这些数据支持了以下假设：海马体在处理有关空间位置的信息方面具有重要作用，并且该任务的正常表现需要完整的海马回路。
