Program in Neuroscience, Indiana University, 1101 E 10th St, Bloomington, IN, 47405, USA.
Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th St, Bloomington, IN, 47405, USA.
Sci Rep. 2023 Apr 15;13(1):6136. doi: 10.1038/s41598-023-33209-9.
Spatial memory requires an intact hippocampus. Hippocampal function during epochs of locomotion and quiet rest (e.g., grooming and reward consumption) has been the target of extensive study. However, during navigation rats frequently rear up onto their hind legs, and the importance of hippocampal activity during these periods of attentive sampling for spatial memory is unknown. To address this, we tested the necessity of dorsal hippocampal activity during rearing epochs in the study phase of a delayed win-shift task for memory performance in the subsequent test phase. Hippocampal activity was manipulated with closed-loop, bilateral, optogenetic inactivation. Spatial memory accuracy was significantly and selectively reduced when the dorsal hippocampus was inactivated during rearing epochs at encoding. These data show that hippocampal activity during periods of rearing can be important for spatial memory, revealing a novel link between hippocampal function during epochs of rearing and spatial memory.
空间记忆需要一个完整的海马体。在运动和安静休息期间（例如，梳理和奖励消费）的海马功能一直是广泛研究的目标。然而，在导航过程中，老鼠经常后腿站立，而在这些时刻对空间记忆进行注意力采样时，海马体活动的重要性尚不清楚。为了解决这个问题，我们在延迟赢移任务的学习阶段测试了在后腿站立期间背侧海马体活动对于后续测试阶段记忆表现的必要性。通过闭环、双侧、光遗传学失活来操纵海马体活动。当在编码期间的后腿站立期间使背侧海马体失活时，空间记忆准确性显著且选择性降低。这些数据表明，后腿站立期间的海马体活动对于空间记忆很重要，揭示了后腿站立期间的海马体功能与空间记忆之间的新联系。
