Fathman C G, Frelinger J G
Annu Rev Immunol. 1983;1:633-55. doi: 10.1146/annurev.iy.01.040183.003221.
To date, the most successful uses of T-cell clones have been in the demonstration that a single type of cell can perform multiple functions. However, their potential usefulness is enormous, and the study of cell interactions using clonal populations has just begun. The development and study of more cloned populations will surely lead to a clearer analysis of cellular interactions in the immune system. The use of T-cell clones and hybridomas to analyze T-cell receptors and/or factors is well under way, and will continue to be an area of intense investigation. Molecular biologists will undoubtedly make more extensive use of T-cell clones in the future, both as a source of cloning material and as transfection recipients. The most exciting area for development, from a medical point of view, is the potential for use of these cell lines or their products in immunotherapy and in providing a mechanism for specifically modulating the immune response.
迄今为止，T细胞克隆最成功的应用在于证明了单一类型的细胞能够执行多种功能。然而，它们的潜在用途极为广泛，利用克隆群体对细胞间相互作用的研究才刚刚起步。更多克隆群体的开发与研究必将使对免疫系统中细胞间相互作用的分析更加清晰。利用T细胞克隆和杂交瘤来分析T细胞受体和/或因子的工作正在顺利进行，并且仍将是一个深入研究的领域。分子生物学家未来无疑会更广泛地利用T细胞克隆，既将其作为克隆材料的来源，也作为转染受体。从医学角度来看，最令人兴奋的发展领域是这些细胞系或其产物在免疫治疗以及提供特异性调节免疫反应机制方面的潜在用途。
