Coy P, Kennelly G M
Cancer. 1980 Feb 15;45(4):698-702. doi: 10.1002/1097-0142(19800215)45:4<698::aid-cncr2820450414>3.0.co;2-8.
From 1963-1974, 141 patients with lung cancer were treated with curative intent in the A. Maxwell Evans Clinic in Vancouver. The clinical presentation, age and sex distribution, histology, and reasons for surgery not being carried out are examined. The results of this treatment are presented. An attempt has been made to isolate a group of patients who have a better prognosis so that treatment selection can be improved. Hemoptysis, cough, dyspnea, and incidental finding on routine chest x-ray were the most common manner of presentation. Thirty-four percent of the patients were over 70 years of age and 13% were women. The crude overall three- and five-year survival rates were 18 and 10% (19 and 9% in the men, 17 and 14% in the women). Patients presenting with dyspnea had a better survival than those presenting with cough and hemoptysis. Patients with lesions less than 3 cm in diameter had a 28% three-year survival, compared with 14% for lesions greater than 5 cm in diameter. The three- and five-year survival rates in patients over 70 years of age were 23 and 17% respectively. The response to treatment and the survival was better in the patients with squamous cell carcinoma. Twenty-two percent were alive at three years and 12% at five years as compared with 9 and 5% for other histologies. Fifty-four percent of the 35 patients with a complete response and with squamous cell carcinoma were alive at three years, compared with only 8% of the 12 patients with other histologies who showed a complete response.
1963年至1974年期间，温哥华的A. 麦克斯韦·埃文斯诊所对141例肺癌患者进行了根治性治疗。本文对患者的临床表现、年龄和性别分布、组织学类型以及未进行手术的原因进行了研究，并展示了治疗结果。我们试图找出一组预后较好的患者，以便改进治疗方案的选择。咯血、咳嗽、呼吸困难以及常规胸部X光检查时偶然发现是最常见的临床表现方式。34%的患者年龄超过70岁，13%为女性。总的三年和五年粗生存率分别为18%和10%（男性为19%和9%，女性为17%和14%）。以呼吸困难为表现的患者生存率高于以咳嗽和咯血为表现的患者。直径小于3厘米的病灶患者三年生存率为28%，而直径大于5厘米的病灶患者三年生存率为14%。70岁以上患者的三年和五年生存率分别为23%和17%。鳞状细胞癌患者对治疗的反应和生存率更好。三年时22%存活，五年时12%存活，而其他组织学类型的患者三年和五年生存率分别为9%和5%。35例完全缓解的鳞状细胞癌患者中，54%在三年时存活，而12例其他组织学类型且完全缓解的患者中只有8%在三年时存活。
