Teasdall R D, Frayha R A, Shulman L E
Medicine (Baltimore). 1980 Mar;59(2):149-59. doi: 10.1097/00005792-198003000-00006.
Ten patients with the diagnosis of systemic sclerosis developed cranial nerve involvement. A trigeminal sensory neuropathy evolved insidiously in all patients and in five of these it was a presenting complaint. The glossopharyngeal nerve was involved in one patient. Taste was impaired in one patient and a unilateral loss of taste with fasciculations of the tongue were noted in another. Tinnitus was a complaint in three patients, two of whom had bilateral impairment of hearing. Facial weakness was noted in five patients. In three, this weakness was bilateral, while in the others the weakness was unilateral, and a past history of acute onset was obtained. The microangiopathy of systemic sclerosis is felt to be primarily responsible for these neurological deficits. The deposition of fibrous tissue may be a secondary phenomenon and contribute to the process by compression of nerves.
10例诊断为系统性硬化症的患者出现了颅神经受累。所有患者均隐匿性地发展为三叉神经感觉神经病变，其中5例以此为首发症状。1例患者累及舌咽神经。1例患者味觉受损，另1例患者出现单侧味觉丧失伴舌肌束颤。3例患者主诉耳鸣，其中2例有双侧听力损害。5例患者出现面部无力。3例为双侧无力，其余为单侧无力，且有急性起病的既往史。系统性硬化症的微血管病变被认为是这些神经功能缺损的主要原因。纤维组织沉积可能是一种继发现象，通过压迫神经促进病变进展。
