Reid R, Laverty C R, Coppleson M, Isarangkul W, Hills E
Obstet Gynecol. 1980 Apr;55(4):476-83.
Human papillomavirus (HPV) infections of the genital tract frequently involve cervical epithelium and produce a macroscopically flat lesion that the authors have called noncondylomatous cervical wart virus infection (NCWVI). Over a 6-month period, 92 of 7281 routine cervical smears (1.3%) and 46 of 183 colposcopically directed punch biopsies (25%) showed morphologic evidence of wart virus infection. The etiologic role of HPV was confirmed by the demonstration of virus particles in 24 of 53 cases (45%) examined by electron microscopy. The colposcopic features of NCWVI consist principally of epithelial opacity and vascular atypia, leading to frequent confusion with cervical intraepithelial neoplasia. Differences in surface contour, color, vascular patterns, and topography generally permit colposcopic differentiation. These 2 conditions sometimes coexist; whether the association is causal or casual in not presently known.
生殖道的人乳头瘤病毒（HPV）感染常累及宫颈上皮，并产生一种肉眼可见的扁平病变，作者将其称为非湿疣性宫颈疣病毒感染（NCWVI）。在6个月的时间里，7281份常规宫颈涂片中有92份（1.3%）以及183份阴道镜引导下的穿刺活检中有46份（25%）显示有疣病毒感染的形态学证据。通过电子显微镜检查，53例中有24例（45%）发现病毒颗粒，从而证实了HPV的病因学作用。NCWVI的阴道镜特征主要包括上皮不透明和血管异型性，这常导致与宫颈上皮内瘤变混淆。表面轮廓、颜色、血管形态和部位的差异通常有助于阴道镜鉴别。这两种情况有时并存；目前尚不清楚这种关联是因果关系还是偶然关系。
