Schmeling W T, Hosko M J
Brain Res. 1980 Apr 14;187(2):431-42. doi: 10.1016/0006-8993(80)90213-9.
Thermosensitive anterior hypothalamic neurons (pre-optic region) were studied in urethane and chloralose anesthetized cats in an attempt to characterize the hypothermic action of delta 9-THC at the neuronal level. One hundred and seventy-eight single neurons were isolated and subjected to thermal challenge, 66 were found to reproducibly alter firing frequency at a significant level (thermosensitivity (T.S.) greater than 0.75). Twenty-one of these units met the criteria for primary thermodetectors, 34 were heat-sensitive interneurons, and 11 were cold-sensitive interneurons. Administration of delta 9-THC (1.0-2.0 mg/kg i.v.) decreased the spontaneous firing and increased the T.S. of the primary thermodetector units. delta 9-THC also increased the spontaneous firing frequency as well as the T.S. of heat-sensitive interneurons, while decreasing both the T.S. and spontaneous firing of cold-sensitive interneurons. The decreased spontaneous firing of primary thermodetectors could result from altered facilitory or inhibitory influences converging on these cells. The increased thermosensitivity is consistent with the hypothesis that the pre-optic region modulates cannabinoid-induced hypothermia.
在氨基甲酸乙酯和水合氯醛麻醉的猫身上，对热敏性下丘脑前部神经元（视前区）进行了研究，试图在神经元水平上表征Δ⁹-四氢大麻酚的低温作用。分离出178个单个神经元并对其进行热刺激，发现其中66个在显著水平上可重复改变放电频率（热敏性（T.S.）大于0.75）。这些单元中有21个符合初级热探测器的标准，34个是热敏性中间神经元，11个是冷敏性中间神经元。静脉注射Δ⁹-四氢大麻酚（1.0 - 2.0毫克/千克）可降低初级热探测器单元的自发放电并增加其热敏性。Δ⁹-四氢大麻酚还增加了热敏性中间神经元的自发放电频率以及热敏性，同时降低了冷敏性中间神经元的热敏性和自发放电。初级热探测器自发放电的降低可能是由于汇聚到这些细胞上的促进或抑制性影响发生了改变。热敏性增加与视前区调节大麻素诱导的体温过低这一假设一致。
