猪痢疾密螺旋体在豚鼠中的实验性感染。
Experimental infection with Treponema hyodysenteriae in guinea pigs.
作者信息
Joens L A, Songer J G, Harris D L, Glock R D
出版信息
Infect Immun. 1978 Oct;22(1):132-5. doi: 10.1128/iai.22.1.132-135.1978.
Abstract
Outbred and inbred (Hartley strain) guinea pigs (GP) were inoculated intragastrically with pathogenic and nonpathogenic Treponema hyodysenteriae. GP 3 to 16 weeks old received T. hyodysenteriae after a fasting period of 36 to 72 h. Infected GP with pathogenic T. hyodysenteriae developed a diarrheal and/or depressive condition, with mucus but not blood in the feces. Of 88 GP, 40 had gross lesions resembling those of swine dysentery. Lesions were limited mainly to the large intestine. TP used as controls or inoculated with nonpathogenic T. hyodysenteriae did not develop these lesions in the large intestine. These studies suggest that the GP may be used as an animal model for swine dysentery.
摘要
将远交系和近交系（哈特利品系）豚鼠经胃内接种致病性和非致病性猪痢疾短螺旋体。3至16周龄的豚鼠在禁食36至72小时后接受猪痢疾短螺旋体接种。感染致病性猪痢疾短螺旋体的豚鼠出现腹泻和/或抑郁症状，粪便中有黏液但无血液。在88只豚鼠中，40只出现了类似于猪痢疾的肉眼可见病变。病变主要局限于大肠。用作对照或接种非致病性猪痢疾短螺旋体的豚鼠在大肠中未出现这些病变。这些研究表明，豚鼠可用作猪痢疾的动物模型。
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