Lupton H W, Barnes H J, Reed D E
Cornell Vet. 1980 Jan;70(1):77-95.
Experimental infection of rabbits with infectious bovine rhinotracheitis virus (IBRV) produced diverse manifestations of disease which included abortion, conjunctivitis, dermatitis, vulvovaginitis, systemic infection, neonatal death and respiratory tract infection. Each disease syndrome was studied using virus isolation, fluorescent antibody examination and histologic examination. Conjunctivitis, dermatitis and vulvovaginitis lesions were characterized by edema, infiltration of mucosa and submucosa with inflammatory cells and ulceration of epithelium. Systemic infection resulted in severe necrosis of liver and adrenal glands with large numbers of cells containing intranuclear inculsions. Pregnant rabbits aborted within 48 hours following inoculation of IBRV. Virus infection and viral lesions were not demonstrated in aborted fetuses.
用传染性牛鼻气管炎病毒（IBRV）对家兔进行实验性感染，会引发多种疾病表现，包括流产、结膜炎、皮炎、外阴阴道炎、全身感染、新生仔兔死亡以及呼吸道感染。每种疾病综合征都通过病毒分离、荧光抗体检测和组织学检查进行研究。结膜炎、皮炎和外阴阴道炎病变的特征为水肿、黏膜和黏膜下层有炎性细胞浸润以及上皮溃疡。全身感染导致肝脏和肾上腺严重坏死，大量细胞含有核内包涵体。怀孕母兔在接种IBRV后48小时内流产。流产胎儿中未发现病毒感染和病毒病变。
