Schwartz G F, Patchesfsky A S, Feig S A, Shaber G S, Schwartz A B
Cancer. 1980 Jun 15;45(12):2913-6. doi: 10.1002/1097-0142(19800615)45:12<2913::aid-cncr2820451202>3.0.co;2-0.
One hundred eighty-nine biopsies have been performed for clinically occult mammary lesions, detectable by mammography but not clinically apparent. Fifty-two cancers were demonstrated within this group, including 26 invasive ductal cancers, seven micro-invasive ductal cancers, 14 non-invasive ductal cancers, and five lobular carcinomas in situ. All mastectomy specimens were examined for multicentric foci of breast cancer in quadrants other than that in which the primary lesion was located. Of the invasive ductal cancers, 40% were multicentric. Of the micro-invasive ductal cancers, 57.1% were multicentric. Of the non-invasive ductal cancers, 45.5% were multicentric. The one mastectomy specimen from a patient with lobular carcinoma in situ did not have evidence of residual disease. The overall incidence of multicentricity in the 43 specimens examined was 44.2%. These findings suggested that any therapeutic procedure for either invasive or non-invasive ductal carcinoma that does not include total mastectomy may leave behind foci of cancer, which are a threat to the patient.
对189例临床隐匿性乳腺病变进行了活检，这些病变在乳腺钼靶检查中可检测到，但临床上不明显。该组中有52例癌症，包括26例浸润性导管癌、7例微浸润性导管癌、14例非浸润性导管癌和5例小叶原位癌。对所有乳房切除术标本进行检查，以寻找原发性病变所在象限以外的乳腺癌多中心病灶。浸润性导管癌中，40%为多中心性。微浸润性导管癌中，57.1%为多中心性。非浸润性导管癌中，45.5%为多中心性。1例小叶原位癌患者的乳房切除术标本没有残留疾病的证据。在检查的43个标本中，多中心性的总体发生率为44.2%。这些发现表明，任何不包括全乳房切除术的浸润性或非浸润性导管癌治疗方法都可能留下癌灶，这对患者构成威胁。
