Umpleby H C, Ranson D L, Williamson R C
Br J Surg. 1985 Sep;72(9):715-8. doi: 10.1002/bjs.1800720915.
The clinical and pathological features of 54 mucinous carcinomas of the large intestine were compared with those of 576 non-mucinous carcinomas. Tumours were only categorized as mucinous if they contained at least 60 per cent of mucin by volume. Those with a moderate mucin content (60-80 per cent) were indistinguishable in behaviour from 'non-mucinous' tumours. By contrast, those with a high mucin content (greater than 80 per cent) showed several differences from non-mucinous cancers: they had a more proximal distribution through the large intestine, they comprised a greater fraction of cancers in the under 50 age group (24 versus 7 per cent: P less than 0.01), they were more likely to be Dukes' stage 'D' (58 versus 31 per cent: P less than 0.01) and local fixity was commoner (70 versus 37 per cent: P less than 0.001). Consequently the overall resection rate was reduced from 90 to 73 per cent (P less than 0.01), the curative resection rate from 69 to 42 per cent (P less than 0.01) and the 5-year survival rate from 37 to 18 per cent (P less than 0.05). Colorectal carcinomas of high mucin content require wide excision, tend to recur locally and carry a poor prognosis.
将54例大肠黏液腺癌的临床和病理特征与576例非黏液腺癌的特征进行了比较。仅当肿瘤的黏液体积含量至少为60%时才被归类为黏液性肿瘤。黏液含量中等（60%-80%）的肿瘤在行为上与“非黏液性”肿瘤无法区分。相比之下，黏液含量高（大于80%）的肿瘤与非黏液性癌有几个不同之处：它们在大肠中的分布更靠近近端，在50岁以下年龄组的癌症中所占比例更大（24%对7%：P<0.01），更有可能处于Dukes分期的“D”期（58%对31%：P<0.01），局部固定更为常见（70%对37%：P<0.001）。因此，总体切除率从90%降至73%（P<0.01），根治性切除率从69%降至42%（P<0.01），5年生存率从37%降至18%（P<0.05）。高黏液含量的结直肠癌需要广泛切除，容易局部复发，预后较差。
