Legakis N J, Kafetzis D A, Papadatos C J, Papavassiliou J T
Chemotherapy. 1980;26(5):334-43. doi: 10.1159/000237925.
The in vitro antibacterial activity of HR-756 compared to cefoxitin and cefuroxime. 122 multiresistant clinical isolates including Enterobacteriaceae (104) and P. aeruginosa (18), which present particular problems in antibiotic chemotherapy, were selected for study. HR-756 inhibited all the stains of S. marcescens, P. mirabilis and indole-positive Proteus spp. at a concentration of 1,3 and 12 micrograms/ml, respectively; beta-lactamase-producing strains were also susceptible. 90% of K. pneumoniae and more than half of the Enterobacter and P. aeruginosa were inhibited from the drug at a concentration 16 microgram/ml. Cefoxitin and cefuroxime were less active than HR-756. Cefoxitin was more effective against S. marcescens and P. mirabilis while the same was the case with cefuroxime against K. pneumoniae strains. The greater efficiency of HR-756 over cefoxitin and cefuroxime against these multiply resistant isolates seems to be due not only to its indifference to the beta-lactamases but also to its easier penetrability into the bacterial cell.
HR-756与头孢西丁和头孢呋辛的体外抗菌活性比较。选取了122株多重耐药临床分离株进行研究，其中包括肠杆菌科细菌（104株）和铜绿假单胞菌（18株），这些细菌在抗生素化疗中存在特殊问题。HR-756分别在1微克/毫升、3微克/毫升和12微克/毫升的浓度下抑制了所有粘质沙雷氏菌、奇异变形杆菌和吲哚阳性变形杆菌属菌株；产β-内酰胺酶的菌株也对其敏感。90%的肺炎克雷伯菌以及超过半数的肠杆菌和铜绿假单胞菌在16微克/毫升的浓度下被该药物抑制。头孢西丁和头孢呋辛的活性低于HR-756。头孢西丁对粘质沙雷氏菌和奇异变形杆菌更有效，而头孢呋辛对肺炎克雷伯菌菌株也是如此。HR-756对这些多重耐药分离株的效率高于头孢西丁和头孢呋辛，这似乎不仅是因为它对β-内酰胺酶不敏感，还因为它更容易穿透细菌细胞。
