Kuipers J S
Curr Med Res Opin. 1981;7(3):196-203. doi: 10.1185/03007998109114263.
The sensitivity of a number of beta-lactamase producing strains of Enterobacter aerogenes, Enterobacter cloacae, Enterobacter species, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa and Serratia marcescens to cefamandole, cefoxitin, cefuroxime, cefotaxime and cefoperazone was determined in vitro. All bacterial cultures were examined for beta-lactamase production using the chromogenic cephalosporin compound 87/312. All strains were typed by means of antibiotic and chemotherapeutic sensitivities. Only non-identical strains were used. A tray method was used to determine the quantity of antimicrobial product necessary for a complete growth inhibition at various culture dilutions. The results showed that all strains of H. influenzae, especially in the dilution 2.10(6), were sensitive to the five cephalosporins. The other species and genus of bacteria had a varying sensitivity to the five cephalosporins. Cefoperazone had potent activity against Ps. aeruginosa. Differences between the five cephalosporins with regard to the effect of culture dilution were only small.
对一些产β-内酰胺酶的产气肠杆菌、阴沟肠杆菌、肠杆菌属、大肠杆菌、流感嗜血杆菌、肺炎克雷伯菌、奇异变形杆菌、普通变形杆菌、铜绿假单胞菌和粘质沙雷氏菌菌株，在体外测定了它们对头孢孟多、头孢西丁、头孢呋辛、头孢噻肟和头孢哌酮的敏感性。使用显色头孢菌素化合物87/312检测所有细菌培养物的β-内酰胺酶产生情况。所有菌株通过抗生素和化疗敏感性进行分型。仅使用不相同的菌株。采用平板法测定在不同培养物稀释度下完全抑制生长所需的抗菌产物量。结果表明，所有流感嗜血杆菌菌株，尤其是在2×10⁶稀释度下，对这五种头孢菌素敏感。其他细菌种类和属对这五种头孢菌素的敏感性各不相同。头孢哌酮对铜绿假单胞菌有强效活性。这五种头孢菌素在培养物稀释度影响方面的差异很小。
