Seay A R, Ziter F A, Hill H R
J Neurol Sci. 1978 Jan;35(1):25-30. doi: 10.1016/0022-510x(78)90099-0.
Polymorphonuclear leukocytes (PMNs), obtained from 10 patients with myotonic dystrophy and 39 age-matched controls, were tested for chemotactic activity, chemiluminescence (CL), and phagocytosis. PMNs from 8 of the 10 patients had depressed chemotactic indexes (30 +/- 23) as compared to controls (61 +/- 18) (P less than 0.0003), and 6 of the 10 patients' PMNs produced lower peaks in CL (less than 90%) than those of controls. Phagocytosis and bactericidal activity were evaluated in 7 patients and were normal. Control PMNs incubated in patient serum produced normal chemotactic activity and CL. These results indicate defects in 2 PMN membrane-associated activities in myotonic dystrophy and suggest that the PMN is affected by the generalized membrane abnormality underlying myotonic dystrophy.
从10例强直性肌营养不良患者和39例年龄匹配的对照者中获取多形核白细胞（PMN），检测其趋化活性、化学发光（CL）和吞噬作用。10例患者中有8例的PMN趋化指数（30±23）低于对照者（61±18）（P＜0.0003），10例患者中有6例的PMN产生的CL峰值低于对照者（＜90%）。对7例患者的吞噬和杀菌活性进行了评估，结果正常。在患者血清中孵育的对照PMN产生正常的趋化活性和CL。这些结果表明强直性肌营养不良患者的PMN存在两种膜相关活性缺陷，并提示PMN受强直性肌营养不良潜在的全身性膜异常影响。
